Puppy Power

I am often asked how I stay upbeat and positive in the face of a terminal cancer diagnosis. Keeping busy/distracted and trying new things are definitely key pieces of advice I would offer fellow survivors.

Recently, I started acupuncture and sound therapy with Sharon Czebotar. I was skeptical about acupuncture until being offered the service while inpatient at the NIH. I found the therapy helped with appetite, neuropathy, and more, which convinced me to search out a local expert. Sharon has been simply amazing and she also recommended a separate class on transcendental meditation, which I start next weekend.

Of course, writing has also been cathartic for me. With my memoir now published (phew!), I can focus again on updating this blog more frequently.

Michael Becker holding a 7-week old golden retriever puppy

Whenever my wife Lorie or I start getting a little depressed or down, she redirects the conversation to “happier topics” – and quickly rattles off puppies, kittens, rainbows, and unicorns. Of the four options, I found puppies the easiest to embrace and acquire. So, next weekend we pickup an 8-week old golden retriever puppy to add to our small zoo.

Other than getting one of the 4 males out of the litter of 11 puppies, we don’t know which one will get his forever home with us as of yet. However, we’ve visited the litter on three separate occasions and to be honest – they all seem great.

Let’s face it…you would have to try REALLY hard not to smile with a puppy licking your ear.

Roller Coaster

It’s been a couple of weeks since my last clinical post, so I wanted to provide an update following this week’s NIH appointments.

Michael Becker pleural effusion

Xray images of Michael Becker’s chest showing pleural effusion both before and after drainage

First, surgical insertion of my Aspira® drainage system has dramatically improved the pleural effusion in my left lung. It’s essentially a chest tube/catheter that allows me to drain the fluid buildup on an as-needed basis into drainage bags at home. The image to the right shows before and after chest x-ray images that demonstrate just how blocked my left lung was before being drained (nearly 2/3 blocked). It also shows how my left lung is now “close” to normal following drainage.

Second, I’ve been on prednisone (steroid) to help “sculpt” the inflammatory response, which is also helping keep the fluid from building up so quickly in my left lung. Whereas I was emptying 100 mL or more on a daily basis previously, I am now only draining 15-20 mL every other day or so.

Now that the pleural effusion can be managed, attention returned to whether or not to resume treatment with M7824, a completely novel, first-in-class, bispecific fusion protein (see prior posts for more details). My last infusion of M7824 was several weeks ago.

Following another CT scan and constructive discussion with the NIH team, we came to the conclusion that there is essentially a tug-of-war occurring between the cancer in my lungs and my body’s immune system, the latter of which appears to be benefiting from M7824. The hope is that eventually M7824 will tip the scale in favor of my body’s immune system and control the cancer.

Michael D. Becker receiving IV infusion with M7824 – a novel, first-in-class, bispecific fusion protein on May 16, 2017

Accordingly, the decision was made to keep moving forward with M7824 and I received an infusion on Tuesday, May 16, 2017. As with past administrations, there were no issues and I returned home to Pennsylvania with Lorie later that evening.

The pleural effusion will be monitored closely and managed via the catheter and steroids. As long as there are no major issues in terms of fluid in my lung, I will continue to receive an infusion of M7824 every other week. A repeat CT scan will be done in a month or so to reassess the situation.